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During fertilization, a sperm must first fuse with the plasma membrane and then penetrate the female egg cell in order to fertilize it. Therefore, sperm cells go through a process known as the acrosome reaction which is the reaction that occurs in the acrosome of the sperm as it approaches the egg.‎Variations among species · ‎Mammals · ‎The process · ‎In in vitro fertilization.

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Description:
As the sperm approach the egg, they bind to the zona pellucida in a process known as sperm binding. This triggers the acrosome reaction, in which the enzymes of the acrosome are freed. These enzymes then begin to digest the zona pellucida and allow the sperm to tunnel toward the egg's plasma membrane.

To reach the egg plasma membrane, sperm must penetrate both layers in steps requiring sperm motility, sperm surface enzymes, and probably sperm-secreted.

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